Best fertility supplements are some of the most widely researched and most commonly recommended tools for people trying to conceive (TTC). Whether you’re just beginning your journey or have been trying for months, the right supplements can help regulate hormones, boost egg and sperm quality, support implantation, and improve overall reproductive wellness.

The body needs targeted nutrients to function optimally during conception — and deficiencies in key vitamins like folate, vitamin D, or omega-3s can significantly impact fertility. This article breaks down ten science-backed TTC supplements that support both female and male fertility. It pairs perfectly with our hormone-balancing article, 8 Powerful Benefits of Cycle Syncing, allowing you to build a complete reproductive wellness routine.

1. Folate (Not Folic Acid) — The #1 TTC Vitamin

Folate is necessary for DNA formation, cell division, ovulation, and early embryo development.
Unlike folic acid (the synthetic version), methylated folate is easier for most people to absorb.

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Benefits:

• Supports healthy ovulation

• Reduces risk of neural tube defects

• Improves egg quality

• Supports early pregnancy development

According to the Mayo Clinic, folate is essential for all women trying to conceive.
Source: https://www.mayoclinic.org/

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2. CoQ10 — Enhances Egg & Sperm Quality

CoQ10 is one of the most researched fertility supplements.
It improves mitochondrial function in eggs and sperm — basically boosting their energy production.

Benefits:

• Improves egg quality

• Supports implantation

• Increases sperm motility

• Helps counter age-related fertility decline

Women over 30 benefit the most.

3. Vitamin D — A Fertility Hormone in Disguise

Around 40–60% of TTC couples have low vitamin D, which impacts ovulation, hormone balance, and menstrual cycle regulation.

Benefits:

• • Supports ovarian function

  • Helps regulate menstrual cycles

  • Improves sperm count & testosterone

• Boosts immune balance during implantation

Harvard Health identifies vitamin D as critical for reproductive wellness.
Source: https://www.health.harvard.edu/

4. Omega-3 Fatty Acids — Reduces Inflammation & Improves Egg Quality

Inflammation affects hormones, cycles, cervical mucus, and egg quality.
Omega-3s, especially from fish oil, help reduce inflammation and support reproductive health.

Benefits:

• Improves cervical mucus

• Supports embryo development

• Increases blood flow to ovaries

• Reduces PMS inflammation

5. Vitamin E — Protects Eggs From Oxidative Stress

Vitamin E is a powerful antioxidant that protects egg cells and improves uterine lining health.

Benefits:

• Improves endometrial thickness

• Supports hormonal balance

• Helps reduce free radicals

• Enhances cervical mucus quality

Best Fertility Supplements for TTC — Male Fertility Boosters

10 Best Fertility Supplements For TTC Backed By Science 2 Fertiease

6. Zinc — Essential for Ovulation & Sperm Production

Zinc deficiency is common and strongly linked to reproductive challenges.

Benefits:

• Increases sperm count

• Supports testosterone

• Helps regulate ovulation

• Boosts egg development

This is a must-have for BOTH partners.

7. Selenium — Improves Egg & Sperm DNA Integrity

Selenium is essential for preventing oxidative stress, which can damage reproductive cells.

Benefits:

• Improves sperm morphology

• Supports thyroid hormones

• Enhances egg development

Found naturally in Brazil nuts.

8. Myo-Inositol — A TTC Favorite for Hormone Balance

One of the biggest TTC supplements today.
Women with irregular cycles or PCOS especially benefit.

Benefits:

• Encourages regular ovulation

• Improves egg quality

• Enhances insulin sensitivity

• Helps regulate estrogen & progesterone

Often paired with D-chiro inositol.

9. Iron — Supports Ovulation & Early Pregnancy Development

Iron deficiency is a leading cause of anovulation (lack of ovulation).

Benefits:

• Boosts ovulation

• Prevents early pregnancy fatigue

• Supports egg development

Women with heavy periods benefit most.

10. Probiotics — The Gut–Hormone Connection

Gut health impacts estrogen detoxification, nutrient absorption, inflammation, and hormonal balance.

Benefits:

• Reduces estrogen dominance

• Supports progesterone balance

• Improves abdominal inflammation

• Enhances nutrient absorption

A balanced gut → balanced hormones.

More information on hormone balancing:
👉 8 Powerful Benefits of Cycle Syncing (And How to Start Today)

⭐ Final Thoughts

Fertility supplements are not magic — but when combined with nutrition, stress reduction, and hormonal balance, they dramatically improve TTC outcomes. The key is consistency. Most supplements require 8–12 weeks to show measurable improvements in egg quality, sperm quality, and hormone regulation.

Every TTC journey is unique, but nourishing your reproductive system with the right nutrients is one of the most empowering steps you can take.

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